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making this a self-contained model compound for conformational
Fmoc-Tyr(β-D-Glc)-OH
The sugar hydroxyl groups are protected as three acetate esters (Ac3)
corresponding to the α-Gal epitope (Galα1-3Galβ1-4GlcNAc) that is the target of naturally occurring human anti-Gal antibodies and is central to xenotransplantation and anti-Gal immunology research
Sialyl Tn or STn (Neu5Acα2-6GalNAcα-O-Ser) at Ser130 and Neu5Acα2-6GalNAcα-O-Thr at Thr131
ES031000: 4-Methylumbelliferyl α-N-glycolylneuraminic acid Pack Size:2 mg making this a self-contained modelC21H25NO12 483. 42 A 4 methylumbelliferyl (MU) glycoside of N glycolylneuraminic acid (Neu5Gc), a sialic acid variant carrying an extra hydroxyl on the N acyl group and found in most mammals but not normally in humans. Used as a fluorogenic substrate for sialidases (neuraminidases) with selectivity or preference for Neu5Gc containing sialosides; sialidase catalyzed cleavage of the glycosidic bond releases free Neu5Gc and 4 methylumbelliferone. 4
