Creatures with the Persist ability come back from the graveyard after they are destroyed if they have no counters on them, and then receive a -1/-1 counter upon their return
Blood Moon won't be legal in Standard, but it will be legal in draft, so even new players will get to understand why it's so notorious
Best Cipher Uses Dimir control decks in EDH that want to chip in with creature damage can make good use of cipher cards
Overall, it could see play in a dedicated The Agent deck, but its effectiveness may vary based on the overall deck composition and playstyle
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Only time will tell how much of this hype is the result of legitimate demand, and how much of the value is being inflated by a small group of buyers