To be honest, Im not big enough in either world to help sort out the difference, but in terms of impact, I think Lorcana will become the biggest CCG/TCG product of all time because Disney fans are the most hardcore fans of any entertainment property I have ever met
This makes him incredibly easy to build around, given the sheer number of +1/+1 counter support cards available in the Commander format
As for gameplay additions, the set will introduce Dual-ink Cards
Blood Moon is great for stopping powerful land-based strategies like Dark Depths or Mazes End and turning off more basic cards like Evolving Wilds
Vanishing Strike is Mega Mewtwo EXs sole attack which hits for a hefty 150 damage, but, more often than not, will hit for 200 due to its easy-to-fulfill condition
There's a fair amount of healthy debate amongst Eldrazi players as to which of the precon Eldrazi commanders is the best